NURS 6501: MIDTERM EXAM: Please contact Assignment Samurai for help with NURS 6501: Midterm Exam or any other assignment. Email: assignmentsamurai@gmail.com     Insulin resistance in Type 2 Diabetes Mellitus impacts glucose metabolism by: Group of answer choices

• Increasing glucose uptake by cells
• Enhancing insulin receptor sensitivity
• Reducing glucose uptake by muscle and fat cells
• Decreasing hepatic glucose production

  The correct answer is: Reducing glucose uptake by muscle and fat cells Explanation: In Type 2 Diabetes Mellitus (T2DM), insulin resistance occurs when the body's cells, particularly muscle and fat cells, become less responsive to insulin. This reduces the ability of insulin to promote glucose uptake into these cells, leading to higher blood glucose levels.

• Increasing glucose uptake by cells: This would occur in a healthy individual with normal insulin sensitivity. In Type 2 Diabetes, glucose uptake is reduced due to insulin resistance.
• Enhancing insulin receptor sensitivity: In insulin resistance, there is a decrease in insulin receptor sensitivity, not an enhancement.
• Reducing glucose uptake by muscle and fat cells: This is the correct answer. In insulin resistance, muscle and fat cells cannot effectively take up glucose in response to insulin, leading to elevated blood glucose levels.
• Decreasing hepatic glucose production: In T2DM, hepatic (liver) glucose production is often increased due to impaired insulin signaling, not decreased.

Conclusion: In Type 2 diabetes, insulin resistance reduces glucose uptake by muscle and fat cells, contributing to elevated blood glucose levels.