NURS 6501: MIDTERM EXAM: Please contact Assignment Samurai for help with NURS 6501: Midterm Exam or any other assignment. Email: assignmentsamurai@gmail.com       What is the result of increased intraglomerular capillary pressure in chronic kidney disease (CKD)? Group of answer choices

• Faster filtration rate of plasma
• Stabilization of kidney function
• Accelerated sclerosis of the remaining nephrons
• Enhanced nephron regeneration

  The correct answer is: Accelerated sclerosis of the remaining nephrons. Explanation: In chronic kidney disease (CKD), increased intraglomerular capillary pressure leads to hyperfiltration in the remaining functional nephrons. This puts additional stress on the glomeruli, which can eventually cause glomerulosclerosis (scarring of the glomerular structures). Over time, this process accelerates kidney damage, contributing to the progressive decline in kidney function. Why the other options are incorrect:

• Faster filtration rate of plasma: While increased intraglomerular pressure initially leads to hyperfiltration (a faster filtration rate) in the remaining nephrons, this is not sustainable in the long term. The sustained hyperfiltration ultimately leads to damage, rather than continued increased filtration.
• Stabilization of kidney function: The opposite occurs. Increased intraglomerular pressure contributes to the progression of kidney damage rather than stabilization, leading to worsening function over time.
• Enhanced nephron regeneration: Nephrons do not regenerate in response to increased pressure. Instead, sustained damage results in glomerulosclerosis and loss of nephron function, making regeneration highly unlikely.

Conclusion: Increased intraglomerular capillary pressure leads to hyperfiltration and glomerulosclerosis in remaining nephrons, which accelerates the progression of kidney damage in CKD.