NURS 6501: Final Exam: Please contact Assignment Samurai for help with NURS 6501: Final Exam or any other assignment. Email: assignmentsamurai@gmail.com Which of the following is an example of a recurrent T-cell predominant CNS inflammatory disease? Group of answer choices

• Neuromyelitis optica (Devic disease)
• Multiple sclerosis
• Acute demyelinating encephalomyelitis (ADEM)
• Neurosarcoidosis

The correct answer is: Multiple sclerosis   Explanation: Multiple sclerosis (MS) is the prototypical recurrent, T-cell-mediated CNS inflammatory demyelinating disease, characterized by:

• CD4+ and CD8+ T-cell infiltration targeting myelin in the brain/spinal cord.
• Episodic relapses (in relapsing-remitting MS) with plaques visible on MRI.
• Th1/Th17-driven autoimmunity against myelin proteins (e.g., MBP, PLP).

Why Not the Others?

• Neuromyelitis optica (NMO/Devic disease):
  • Antibody-mediated (anti-AQP4 IgG) pathology (B-cell/plasma cell predominant).
  • Targets astrocytes, not just myelin.
• Acute disseminated encephalomyelitis (ADEM):
  • Monophasic (typically post-infectious), not recurrent.
• Neurosarcoidosis:
  • Non-caseating granulomas (macrophage/T-cell mix), not purely T-cell-driven demyelination.

Key Insight: While all are CNS inflammatory disorders, MS is uniquely recurrent and T-cell predominant. Thus, multiple sclerosis is the correct answer.